216例药品不良反应报告分析

Analysis of 216 Cases of Adverse Drug Reactions

目的:了解定西市人民医院药品不良反应(ADR)发生的特点及规律,为合理用药提供参考。方法:对2011年至2013年收集的216例ADR报告进行分类统计和分析。结果:216例ADR报告中共涉及药品97种,男性发生率(127例,占58.8%)多于女性(89例,占41.2%);60岁以上人群所占比例最大,有80例(占37.03%);静脉滴注给药途径最易引发ADR(109例,占48.23%);抗感染药引发的ADR例数最多(79例,占33.3%);ADR累及器官和(或)系统以皮肤及其附件损害最为常见(90例,占40.72%);严重的ADR有8例(占3.7%);所有ADR均治愈或好转。结论:ADR发生与多种因素有关,医疗机构应完善医、药、护合作的ADR监测体系,加强ADR监测,发挥临床药师用药监护作用,合理用药,减少或避免ADR的发生。

Objective： To investigate characteristics and patterns of the adverse drug reactions（ADRs） in Dingxi City People＇s Hospital, so as to provide references for rational drug use. Methods： The 216 cases of ADR reports collected from 2011 to 2013 were classifi ed, summarized and analyzed. Results： The 216 cases of ADR reports involved 97 kinds of drugs, and the incidence for males（127 cases, 58.8%） was higher than for females（89 cases, 41.2%）. Population over 60 accounted for the largest proportion（80 cases, 37.03%）. Intravenous infusion was the easiest way to led to ADRs（109 cases, accounting for 48.23%）. ADRs induced by anti-infective drugs ranked fi rst（79 cases, accounting for 33.3%）. Cases of lesions of skin and its appendages were the most common（90 cases, accounting for 40.72%） among ADRs involving organs and/or systems. There were 8 cases of severe ADRs（3.7%）. All ADRs were cured or improved. Conclusion： The occurrence of ADRs is related with many factors. The medical institutions should perfect the ADRs supervision system in cooperation of medicine, pharmacy, and nursing, strengthen the monitoring of ADRs, exert the role of clinical pharmacists in drug monitoring, and promote rational drug use, so as to reduce or avoid the occurrence of ADRs.