中老年膝原发性骨关节炎患病率及危险因素分析

An analysis on prevalence and risk factors for knee primary osteoarthritis in people over 50 years old

目的探讨中老年人膝原发性骨关节炎(OA)患病率及相关危险因素。方法采用标准化问卷调查和相关检测,分析2257例江苏高邮农村50岁及以上汉族居民的膝原发性OA患病率及相关危险因素。结果膝OA患病率均随年龄增长而增加。男、女膝OA患病率无统计学差异[20.4%(249/1221)vs.20.3%(210/1036)](P>0.05)。膝OA组的年龄、腰围、总胆固醇、低密度脂蛋白胆固醇(LDL-C)等指标均高于非膝OA组;膝OA组患者超重、向心性肥胖、高LDL-C、高血压等疾病的患病率亦高于非膝OA组(P<0.05)。多因素回归分析显示,年龄(OR=1.03,95%CI=1.01-1.04,P<0.01)、向心性肥胖(OR=1.39,95%CI=1.12-1.73,P<0.01)和高LDL-C(OR=1.47,95%CI=1.02-2.10,P<0.05)与膝OA密切相关。结论衰老、肥胖及代谢紊乱是中老年膝OA的危险因素。

Objective To investigate the prevalence and risk factors for knee primary osteoarthritis（OA）in people over 50 years old.Methods With a standerdized questionnaire survey,physical examination and laboratory tests,the prevalence and risk factors for knee primary OA were investigated and analyzed in 2257 people over 50 years old in Gaoyou area,Jiangsu China.Results The prevalence of knee OA increased as age increased,which was 20.4%in males（249/1221）and 20.3%in females（210/1036）（P〉0.05）.The age,waist circumference,total cholesterol and low density lipoprotein cholesterol（LDL-C）were significantly higher in people with knee OA than those without knee OA.The prevalence of overweight,central obesity,high LDL-C and hypertension was higher in people with knee OA than those without knee OA as well.Multivariate logistic regression analysis demonstrated that the prevalence of knee OA was positively correlated to age（OR=1.03,95%CI=1.01-1.04,P〈0.01）,central obesity（OR=1.39,95%CI=1.12-1.73,P〈0.01）,and high LDL-C（OR=1.47,95% CI=1.02-2.10,P〈0.05）.Conclusion Increased age,obesity and metabolic disorders are the risk factors for knee OA in people over 50 years old.