导管消融治疗心房颤动的累积Meta分析

Catheter ablation for atrial fibrillation:a cumulative Meta-analysis

目的评价导管消融治疗心房颤动(房颤)的有效性与安全性。方法通过Cochrane图书馆、Medline和Embase等数据库检索导管消融与非消融治疗房颤的临床随机对照试验文献,对治疗的成功率进行累积Meta分析。结果 12个临床随机对照试验符合本文的纳入标准,共计1742例。导管消融治疗房颤在随访12个月时的成功率高于非消融治疗组[OR=8.12,95%CI(4.38-15.04),P<0.01]。导管消融在大部分试验中都表现出了良好的安全性。结论导管消融在药物复律失败的房颤患者中具有较高的有效性与良好的安全性,但是该技术能否成为房颤的一线复律治疗证据还不充分。

Objective To evaluate the efficacy and safety of catheter ablation（CA）in the treatment of patients with atrial fibrillation（AF）.Methods The randomized controlled trials about CA and non-ablation treatment for AF patients were searched from the database of the Cochrane Library,Medline and Embase and so on.A cumulative Meta-analysis was adopted to analyze the treatment success rate.Results A total of 12 clinical randomized controlled trials（1742cases）was finally enrolled.The treatment success rate of CA for the patients with AF in the follow-up of 12 months was significantly higher than that of non-ablation treatment[OR=8.12,95% CI（4.38-15.04）,P〈0.01].A satisfactory safety could be concluded in the most trials about CA for AF.Conclusion CA for AF patients has higher efficacy and good safety,who are failed to have successful AF conversion by drugs.The evidence of whether it can be taken as the first-line treatment of AF is not sufficient.