硝普钠治疗高血压急症的疗效

Efficacy of sodium nitroprusside in treating hypertensive emergency

目的探讨硝普钠治疗高血压急症的疗效。方法高血压急症患者140例均分为两组:A组采用硝普钠降压,开始剂量为0.25μg·kg-1·min-1;B组采用硝酸甘油降压,开始剂量为5-10μg·kg-1·min-1。比较两组降压效果和不良反应发生情况。结果两组均取得预期降压效果,总有效率均为100%;降压期间,A组心率慢于B组[(85.94±12.76)次/分vs.(89.21±13.79)次/分](P<0.05)。结论硝普钠治疗高血压急症安全有效。

Objective To explore the efficacy and safety of sodium nitroprusside in the treatment of hypertensive emergency.Methods A total of 140 patients with hypertensive emergency was equally assigned into two groups.The hypertensive emergency in group A was treated with sodium nitroprusside started in a dose of 0.25μg·kg-1·min-1 and that in group B with nitroglycerin started in a doses of 5-10μg·kg^-1· min^-1.The efficacy of blood pressure reduction and related adverse effects were compared between two groups.Results The efficacy was satisfactory in the control of hypertensive emergency with an overall effectiveness rate of 100% in both groups.The heart rate during treatment was lower in group A than that in group B[（85.94±12.76）beats/min vs.（89.21±13.79）beats/min]（P〈0.05）.Conclusion Sodium nitroprusside is effective and safe in the treatment of patients with hypertensive emergency.