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脂肪肉瘤的分子机制与靶向治疗的研究进展

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摘要 对脂肪肉瘤发生、发展和预后的相关分子机制研究不仅有助于分型诊断和预后评估,也有助于为靶向治疗提供新的干预目标。现将脂肪肉瘤的分子机制与靶向治疗的研究进展综述如下。
出处 《江苏医药》 CAS 2015年第14期1685-1688,共4页 Jiangsu Medical Journal
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参考文献22

  • 1Erickson-Johnson MR,Seys AR,Roth CW,et al.Carboxypeptidase M:a biomarker for the discrimination of welldifferentiated liposarcoma from lipoma[J].Mod Pathol,2009,22(12):1541-1547.
  • 2Mariani O,Brennetot C,Coindre JM,et al.JUN oncogene amplification and overexpression block adipocytic differentiation in highly aggressive sarcomas[J].Cancer Cell,2007,11(4):361-374.
  • 3He M,Aisner S,Benevenia J,et al.Epigenetic alteration of p16INK4agene in dedifferentiation of liposarcoma[J].Pathol Res Pract,2009,205(6):386-394.
  • 4Singer S,Socci ND,Ambrosini G,et al.Gene expression profiling of liposarcoma identifies distinct biological types/subtypes and potential therapeutic targets in well differentiated and dedifferentiated liposarcoma[J].Cancer Res,2007,67(14):6626-6636.
  • 5Brill E,Gobble R,Angeles C,et al.ZIC1overexpression is oncogenic in liposarcoma[J].Cancer Res,2010,70(17):6891-6901.
  • 6Barretina J,Taylor BS,Banerji S,et al.Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy[J].Nat Genet,2010,42(8):715-721.
  • 7Ray-Coquard I,Blay JY,Italiano A,et al.Effect of the MDM2antagonist RG7112on the P53pathway in patients with MDM2-amplified,well-differentiated or dedifferentiated liposarcoma:an exploratory proof-of-mechanism study[J].Lancet Oncol,2012,13(11):1133-1140.
  • 8Demetri GD,Fletcher CD,Mueller E,et al.Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma[J].Proc Natl Acad Sci USA,1999,96(7):3951-3956.
  • 9Debrock G,Vanhentenrijk V,Sciot R,et al.A phase II trial with rosiglitazone in liposarcoma patients[J].Br J Cancer,2003,89(8):1409-1412.
  • 10Pishvaian MJ,Cotarla I,Wagner AJ,et al.Final reporting of a phase I clinical trial of the oral PPAR-gamma agonist,CS-7017,in patients with advanced malignancies[J].J Clin Oncol,2010,28(15Suppl):2526.

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