HIV感染者弓形虫伴随感染的分子流行病学状况

Molecular epidemiology situation of the HIV patients accompanied with Toxoplasma gondii infection

弓形虫是一种重要的机会性致病原虫，是艾滋病患者常见的一种机会性感染寄生虫，其感染率占全部机会性感染的10％～30％。通常根据基因型的不同将弓形虫分为Ⅰ型、Ⅱ型和Ⅲ型，HIV感染者感染的弓形虫多为I型．I型弓形虫与其它类型弓形虫的致病性有很大差异．造成差异的根本原因是致病基因的不同，这些差异基因主要包括SAG1、SAG2、B1等。该文从弓形虫感染现状、伴随感染弓形虫的主要类型和各个类型之间的差异基因等方面．阐述HIV感染者弓形虫伴随感染的分子流行病学状况．

Toxoplasma gondii is one of opportunistic pathogenic protozoan parasites. It is also one of the most common opportunistic infections in AIDS. The proportion of toxoplasmosis accounted for total opportunis- tic infection in HIV patients is 10% to 30%. According to the differences of gene type, Toxoplasma gondii could be divided into type Ⅰ , type Ⅱ and type Ⅲ. HIV patients are mostly infected with type Ⅰ . There are great differences in pathogenicity between type Ⅰ and the other types which are caused by different genes. The different genes are SA G1, SA G2, B1 and so on. Based on the current situation of HIV patients accompanied with Toxoplasma gondii, the main type of Toxoplasma gondii in HIV patients and the different genes between the various types, we elaborated on the situation of the HIV patients accompanied with Toxoplasma gondii in molecular epidemiology in this paper.