摘要
间充质干细胞(MSC)内在的肿瘤趋向性和固有的低免疫原性,使其可能成为肿瘤靶向治疗的理想载体。MSC本身可通过释放细胞因子发挥一定的抗肿瘤作用,而通过溶瘤病毒、抗血管生成药物、肿瘤坏死因子诱导凋亡配体、IL、IFN及前体药物修饰的MSC抗肿瘤效果进一步加强。另外,MSC联合其他治疗也显示出一定的优势。
Mesenchymal stem cells (MSCs) have inherent tumortrophic migratory properties and low immunogenicity, which allow them to serve as vehicles for delivering effective, targeted therapy to tumors. MSC plays an antitumor role by releasing some cytokines, which can be strengthened by oncolytic virus, antiangiogenesis agent, tumor necrosis factor guided apoptosis ligand, IL, IFN and prodrug. In addition, there are some advantages in combination treatment of MSC and others therapies.
出处
《国际肿瘤学杂志》
CAS
2015年第8期612-615,共4页
Journal of International Oncology
基金
国家自然科学基金(81372460)
关键词
间充质干细胞
肿瘤
赋形剂
Mesenchymal stem cells
Neoplasms
Vehicles