男性乳腺癌的易感基因

Male breast cancer susceptibility genes

男性乳腺癌（MBC）发病罕见，其发病机制和生物学特性尚未明了。目前认为乳腺癌易感基因（BRCA）1、BRCA2，细胞周期检测点激酶2（CHEK2）以及乳腺癌易感基因相关蛋白基因2（PALB2）与男性乳腺癌发病关系密切。而乳腺癌易感基因相互作用蛋白1基因（BRIP1）与男性乳腺癌发病机制尚存争议。

Male breast cancer （MBC） is one of rare malignant carcinomas, of which the pathogenesis and biological characteristics remain elusive. Recently, it has been reported that breast cancer susceptibility gene （BRCA） 1, BRCA2, checkpoint kinase 2 （CHEK2） and partner and localizer of BRCA2 （PALB2） play important roles in the pathogenesis of MBC. Whereas the relationship between BRCA1interacting protein 1 （BRIP1） and MBC is still controversial.