上海人群结直肠癌生存率分析

Colorectal cancer survival analysis in major areas in shanghai China

背景与目的：中国结直肠癌的发病率和死亡率逐年上升，该研究分析了结直肠癌生存率资料，以促进结直肠癌的防治。方法：根据上海市肿瘤登记处收集的2002--2006年结直肠癌登记和生存随访报告资料，采用寿命表法和EdererⅡ法对结直肠癌患者的观察生存率（observed survival，os）和相对生存率（relative survival，RS）及其相关人口学和疾病状况特征资料进行分析，以反映上海地区人群结直肠癌的生存现况。结果：纳入分析的上海市2002--2006年诊断的结肠癌和直肠癌病例分别为16682例和11906例，5年OS分别为48．84％和51．65％，5年RS分别为70．50％和71．31％。各种不同诊断时期别间的生存率差异有统计学意义（P〈0．05）。Ⅰ期患者的生存率明显高于Ⅲ期和Ⅳ期。不同性别、年龄、肿瘤组织学类型和居住区域的结直肠癌患者生存情况差异有统计学意义（P〈0．05）。女性生存率较男性高，〉44～54岁年龄段患者生存率高于其他年龄组，上皮型肿瘤的结肠癌患者生存率高于其他组织学类型的结肠癌患者，非上皮型肿瘤的直肠癌患者生存率高于其他组织学类型的直肠癌患者。过去30年来，上海地区结直肠癌的5年OS和RS都有明显改善。结论：上海市结直肠癌患者的生存水平较高，接近发达国家水平。不同特征人群结直肠癌生存的差异为进一步改善早期筛查和临床诊治提供了发展方向。

Background and purpose： The incidence and mortality of colorectal cancer increased gradually in China, cancer survival rate plays an important role in guiding cancer prevention and treatment. Methods： Data of colorectal cancer cases diagnosed during 2002-2006, follow-up information and death report were from Shanghai Cancer Registry, Life Table and Ederer Ⅱ were used to calculate observed survival （OS） and relative survival （RS）, the related demographic characteristics and status were also analyzed to reflect the survival situations of the colorectal cancer survivors in major areas in Shanghai. Results： In this study, 16 682 colon cancer cases and 11 906 rectum cancer cases were included in analysis, 5-year OS rates for colon cancer and rectum cancer were 48.84% and 51.65%, RS rates were 70.50% and 71.31%. Significant difference in survival had been found among the various diagnostic stages, the survival rate in stage Ⅰ was much higher than those in stage Ⅲ and stage Ⅳ. The survival of colorectal cancer patients with different gender, age, tumor histological and residential areas were also found with differences, female was higher than male, age ranged from 〉44-54 years had the highest survival rates than other age groups. The survival of epithelial tumors was higher than other histologic types in colon cancer, and the survival of non-epithelial tumors was higher than other histologic types in rectum cancer. Over the past 3 decades, the 5-year OS increased dramatically in Shanghai. Conclusion： The level of survival of colorectal cancer in Shanghai is similar with it in developed counties. Colorectal cancer survival rate with different population characteristics may provide suggestions and evidence for further improvement of early screening, diagnosis and treatment.