甘草提取物对唑吡坦在大鼠体内的药动学影响

Effect of Licorice on Zolpidem Pharmacokinetics in Rats

目的研究甘草提取物对唑吡坦在大鼠体内药动学的影响。方法 12只大鼠随机分为对照组与甘草组,分别予生理盐水和甘草提取物(0.5 g·kg-1,qd)7 d后唑吡坦灌胃给药,按时间点连续采样,采用HPLC-FLU测定血药浓度。计算其主要药动学参数,并进行统计学分析。结果合用甘草后,唑吡坦的tmax显著缩短(P<0.05),AUC0→8 h、AUC0→∞显著减小(P<0.05),CL/F显著增高(P<0.05),而Cmax和t1/2变化无统计学差异。结论甘草提取物影响唑吡坦在大鼠体内的代谢,临床上两药合用应注意潜在的药物相互作用风险。

OBJECTIVE To study the effect of licorice on zolpidem pharmacokinetics in rats. METHODS Experimental rats were randomly divided into the control group and treatment group, which was administrated respectively with normal saline and extract of licorice. After pretreated with extract of licorice（0.5 g·kg-1, qd） for 7 d, zolpidem was given to the rats by intragastric administration. The plasma concentrations of zolpidem were determined by HPLC-FLU. Main pharmacokinetic parameters were calculated by statistical analysis. RESULTS After coadministrating with licorice, the tmax of zolpidem was markedly decreased（P0.05）. The AUC0→8 h and AUC0→∞ of zolpidem in treatment group were significantly lower than those in control group（P0.05）. And the CL/F was markedly decreased（P0.05）. There was no significant difference between the two groups of Cmax and t1/2（P0.05）. CONCLUSION Extract of licorice can affect the metabolism of zolpidem. So we should pay attention to the potential herb-drug interaction risk after coadministrating with licorice and zolpidem in clinic.