土三七致肝小静脉闭塞病的血小板及凝血功能临床表现分析

Analysis of the Clinical Manifestations of Platelet and Coagulation Function in Gynura Segetum Merr. Induced Hepatic Venular Occlusive Disease

目的分析土三七所致的肝小静脉闭塞病(hepatic venular occlusive disease,HVOD)的血小板及凝血功能的临床表现。方法搜集35例外伤后服用土三七致HVOD的血小板及凝血功能临床资料,结合文献报道进行分析。结果 35例患者中,32例血小板小于正常值,占91.4%,检测值为(81.94±17.92)×109·L-1;凝血酶原时间延长33例,占94.2%,检测值为(18.73±3.28)s,国际标准化比值检测值为1.76±0.35,部分活化凝血酶原时间检测值为(42.35±6.57)s。结论临床上土三七致HVOD血小板数量减少、凝血功能受抑制,应用活血化瘀、抗凝为主的方案治疗土三七致HVOD有待进一步研究。

OBJECTIVE To analysis of clinical manifestations of platelet and coagulation function in Gynura segetum Merr. induced hepatic venular occlusive disease（HVOD）. METHODS The 35 cases with Gynura segetum Merr. induced HVOD were selected. The clinical data of the patients were analysed referring to reported literature. RESULTS In 35 cases, the platelet count of 32 cases were lower than normal, accounting for 91.4%, the value was（81.94±17.92）×109·L-1. The prothrombin time of 33 cases was prolonged, accounting for 94.2%. The value was（18.73±3.28）s. The international normalized ratio was 1.76±0.35. The activated partial thromboplastin time was（42.35±6.57）s. CONCLUSION The platelets content of Gynura segetum Merr. induced HVOD clinically and the coagulation function is inhibited. The therapy of romoting blood circulation for removing blood stasis and the anticoagulation of Gynura segetum Merr. induced HVOD need to be explored further.