复方丹参滴丸联合西药治疗对冠心病心绞痛随机平行对照研究

CSDP Combined Western Medicine for Angina Pectoris Parallel Randomized Controlled Study

[目的]观察复方丹参滴丸联合西药治疗对冠心病心绞痛疗效。[方法]使用随机平行对照方法,将110例门诊患者按就诊顺序号法简单随机分为两组。对照组55例发作予硝酸甘油,0.5mg/次;缓解期氢氯吡格雷,75mg/次,1次/d;阿托伐他汀钙,20mg/次,1次/d。治疗组55例复方丹参滴丸,270丸/次,3次/d;西药治疗同对照组。连续治疗28d为1疗程。观测临床症状、发作次数、持续时间、左心室射血分数(EF)、每搏量(SV)、左室内径缩短率(FS)、室壁增厚率(△T)、室间隔运动幅度(AIS)、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈29例,显效17例,有效7例,无效2例,总有效率96.36%。对照组痊愈23例,显效14例,有效7例,无效11例,总有效率80.00%。治疗组疗效优于对照组(P<0.01)。症状积分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。心脏彩超检测治疗组改善优于对照组(P<0.01)。[结论]复方丹参滴丸联合西药治疗对冠心病心绞痛疗效满意,无严重不良反应,值得推广。

[Objective] To observe the CSDP combined western medicine for Angina. [Methods]Randomized parallel-group method using the 110 cases of outpatient treatment order number method is simple and randomly divided into two groups. 55 cases in the control group to attack nitroglycerin, 0.5mg/times. Remission clopidogrel hydrogen, 75mg/times, 1 time/d; atorvastatin calcium, 20mg/times, 1 times/d. Treated 55 cases of CSDP, 270 pills/time, 3 times/d; Western medicine with the control group. 28 d for a course of continuous treatment. Observation of clinical symptoms, seizure frequency, duration, left ventricular ejection fraction（EF）, stroke volume（SV）, left ventricle shortening（FS）, wall thickening（△T）, septal motion amplitude（ Ai S）, adverse reactions. A course of treatment to determine efficacy. [Results] The cure 29 cases, 17 cases markedly effective in 7 cases, 2 cases, the total efficiency of 96.36%. Cured 23 cases in the control group, 14 cases markedly effective in 7 cases, 11 cases, the total efficiency of 80.00%. Treatment group than in the control group（P〈0.01）. Symptom scores were improved in both groups（P〈0.01）, the treatment group than the control group improved（P〈0.01）. Echocardiography to detect than the control group, the treatment group improved（P〈0.01）. [Conclusion] CSDP combined western medicine for Angina satisfaction, no side effects, it is worth promoting.