补益脾肾方对阿霉素肾病大鼠肾间质TGF-β_1、HGF影响随机平行对照研究

Benefit Spleen Kidney Party of Adriamycin Nephrosis Rats Renal Interstitial TGF-beta 1 and HGF Adjustment

[目的]观察补益脾肾方对阿霉素肾病大鼠肾间质TGF-β1和HGF的调节作用。[方法]使用前瞻性设计方法,将32例成年雄性SD大鼠按抽签方法简单随机分为四组。空白组、模型组8例,生理盐水,10m L/kg?d-1;中药组8例,补益脾肾组方,10m L/kg d-1;西药组8例,贝那普利,0.2mg/m L,2mg/kg?d-1。6周后处死,留取肾组织。[结果]中药组阿霉素肾病大鼠肾间质TGF-β1和HGF改善优于其他各组(P<0.05)。[结论]扶正化瘀泄浊方对慢性肾衰营养不良状况补益脾肾方对阿霉素肾病大鼠肾间质TGF-β1和HGF有明显改善作用。

[Objective]To observe the regulatory effect of invigorating spleen and kidney recipe on kidney of rats with adriamycin induced nephropathy and interstitial TGF- beta 1 and HGF. [Methods]Using a prospective design method, 32 cases of adult male SD rats by simple method were randomly divided into four groups. Blank group, model group 8 cases, normal saline, 10mL/kgod-1; 8 cases of Chinese medicine group, invigorating spleen and kidney prescription, 10mL/kg d-1; western medicine group of 8 cases, Benner Pury, 0.2mg/mL, 2mg/kg d-1. Animals were sacrificed after 6 weeks, the renal tissue. [Results] The Chinese medicine group rat kidney in adriamycin induced nephropathy and interstitial TGF- beta 1 and HGF is better than the other groups （P 〈 0.05）. [Conclusion] Fuzheng Huayu Xiezhuo Decoction on chronic renal failure, malnutrition spleen decoction has obvious effect on improving the kidney in adriamycin nephrosis rat mesenchymal TGF- beta 1 and HGF.