“藻戟遂芫俱战草”配伍禁忌理论的沿革及现代认识

History of incompabUity among medicinals of ＂Glycyrrhiza antagonistic to Sargassum, Euphorbia Pekinensis, Kansui, and Genkwa＂ and its modern recognition

“藻戟遂芫俱战草”属中药“十八反”，是指甘草与海藻、大戟、甘遂、芫花相反，不宜同用。回顾“藻戟遂芫俱战草”配伍禁忌理论的沿革及现代认识，可知药物“七情”之说出自《神农本草经》，包含着药物配伍禁忌的内容；《本草经集注》首次明确记载甘草反甘遂、芫花、大戟、海藻；“十八反”歌诀将甘草与甘遂、芫花、大戟、海藻相反概括为“藻戟遂芫俱战草”；后世本草著作乃至《中华人民共和国药典》《中药大辞典》《中华本草》等，继承了“藻戟遂芫俱战草”相反药物配伍禁忌理论，而基础研究和临床研究的结论并非完全一致，“藻戟遂芫俱战草”的科学性值得进一步用现代科学方法研究实证。

The allegation of ＂Glycyrrhiza antagonistic to Sargassum, Euphorbia Pekinensis, Kansui, and Genkwa＂, being one of the hypotheses of ＂18 antagonisms＂ in TCM pharmacology, is referring to the antagonistic action among the Radix et Rhizoma Glycyrrhiza and Radix Euphorbiae Kansui, Radix Euphorbiae Pekinensis, Flos Genkwa, and Sargassum when compounded together in a single recipe. By reviewing its history concerted with modem knowledge, it can be found that the theory of ＂seven emotions＂ was originated from Shennong＇s Classic of Materia Medica ; while the Variorum of the Classic of Materia Medica firstly and definitely records that Radix et Rhizoma Glycyrrhizae is forbidden to be used with Radix Kansui, Flos Genkwa, Radix Euphorbiae Pekinensis, Sargassum together in a single formula. It was summarized into a Chinese poetic sentence as above-mentioned later. In the works of later ages, including Chinese Pharmacopoeia, A Great Dictionary of Chinese Materia Medica, and China＇ s Herbology, etc. , all enhance the understanding of the prohibited combination of Radix et Rhizoma Glycyrrhizae and its incompatible herbs. Nevertheless, there are discrepancies between the results of modem experimental and clinical studies on this problem, which, needless to say, should be resolved by further investigations.