细胞共培养模型在口服药物吸收研究中的应用

Application of cell co-culture models in absorption of oral drug

细胞共培养体系能很好地模拟人体小肠生理环境,准确预测药物在肠道内的转运和代谢情况,增强体外细胞模型与整体动物实验研究之间的相关性,近年来在评价口服药物吸收方面发挥着越发重要的作用,已成为新药研发过程中评价药物口服吸收的热点。综述体外模拟肠道环境的细胞共培养模型,并对其应用于口服药物研发的体外评价吸收做出展望。

Cell co-culture system can better simulate the inner environment of human body ,predict drug transport and metabolism in intestinal environment and increase the relation between in vitro cell model and integral animal test .In recent years ,co-culture cell model plays an increasingly important role in evaluating the absorption of oral drugs ,which becomes the highlight in the evaluation of drug oral absorption during new drug discovery .This essay summarized co-culture cell model which simulates intestinal environment and their application ,and looked into the future of their application in evaluating oral drug intestinal absorption during oral drug discovery .