苄基四氢异喹啉类生物碱的药理作用及其研究进展

Research advance on the pharmacological effects of benzyltetrahydroisoquinolines alkaloids

目的介绍苄基四氢异喹啉生物碱的主要药理作用及其研究进展。方法综述苄基四氢异喹啉类化合物的生物活性、作用机制及其临床应用。结果苄基四氢异喹啉类生物碱具有多方面的药理学活性,尤其在抗肿瘤、抗氧化、抗炎、抗病原微生物等方面的研究进展迅速,且临床应用较为广泛。结论苄基四氢异喹啉类化合物具有丰富的生物学活性,研究其药理作用便于更深入地了解该类化合物的作用特点及应用前景,为该领域药物开发提供思路和启示。

Objective To introduce the major pharmacological effects and research progress of benzyltetrahydroisoquino-lines alkaloids .Methods The compounds structure ,biological activity ,mechanism and clinical applications of benzyltetra-hydroisoquinolines were reviewed based on the domestic and foreign research literatures in recent years .Results Benzyltetra-hydroisoquinolines alkaloids exhibit many pharmacological activities .Researches and clinic applications on anti-tumor ,anti-oxi-dation ,anti-inflammation and anti-pathogen have been developed rapidly .Conclusion Benzyltetrahydroisoquinolines alkaloids have exhibited abundant biological activities .Studying its pharmacological effects can further the understanding of its pharma-cological characteristics and application prospects ,and provide thoughts and enlightenment for drug development in this field .