复方甘草酸苷片治疗慢性湿疹的荟萃分析

Meta-analysis of compound glycyrrhizin tablets in treatment of chronic eczema

目的通过荟萃(Meta)分析评价复方甘草酸苷片对慢性湿疹的疗效。方法检索并选取国内公开发表的有关复方甘草酸苷片治疗慢性湿疹的随机对照试验(RCT)文献,根据Cochrane系统评价方法对纳入的文献进行方法学质量评价,并用RevMan 5.0软件进行Meta分析。结果纳入RCT文献9篇,共计830例患者,其中治疗组和对照组均为415例。复方甘草酸苷治疗组在疗效和安全性方面均优于对照组。结论复方甘草酸苷片治疗慢性湿疹有一定疗效,安全性高、不良反应少,但由于纳入分析的文献质量较低,尚需进行严格的、多中心随机双盲对照试验,以提供更有说服力的依据。

Objective To assess the effects of compound glycyrrhizin tablets for chronic eczema patients using the Meta-analysis method .Methods The national literatures related to random control clinical trials on compound glycyrrhizin tablets for treating chronic eczema were retrieved .The method recommend by the cochrane collaboration to perform a Meta-analysis of randomized controlled trail（RCT）in RevMan 5 .0 was applied .Results Nine articles were included ,eight hundred and thirty patients were enrolled ,and there were four hundred and fifteen cases for both the treatment group and control group .The re-sults showed that both curative effect and safety of the treatment group with compound glycyrrhizin were better than that of the control group .Conclusion Compound glycyrrhizin had certain curative effect in the treatment of chronic eczema .It was safe and with less adverse effect .However ,it still needs more strict and multicentre randomized double-blind control trial to provide more effective and convinced evidence .