治疗性多肽对细菌的作用及机制研究进展

Research Progress in the Effects and Mechanisms of Therapeutic Peptides on Bacteria

随着抗生素的广泛使用,病原菌耐药性愈发严重,已成为临床医学亟待解决的问题。治疗性多肽制造成本低、活性高、特异性强、对系统组织毒性小,为人们解决这一难题提供了新的途径,如杆菌肽与金属络合得到的杆菌肽锌对革兰氏阳性菌及耐青霉素葡萄球菌有着有效的杀菌作用。噬菌体表面提供了寻找针对顽固细菌感染的治疗性多肽的新方向。本文主要综述了治疗性多肽对细菌的作用及相关作用机制研究进展。

The wide use of conventional antibiotics has made microbial resistance a serious problem, and this situation has become an urgent problem in clinical medicine. Due to their low cost, high activity, strong specificity and low toxicity to tissues, therapeutic peptides provide a new way to solve this problem, e.g. Zinc bacitra- cin which is complexed by bacitracin and Zinc is effective against gram positive bacteria and penicillin resist- ant staphylococcus. The surface of bacteriophage has provided a new direction to find therapeutic peptides a- gainst stubborn bacterial infection. Advances in the effects and related mechanisms of therapeutic peptides on bacteria are reviewed in this article.