口服多微粒脉冲释药系统中功能性包衣膜的应用研究进展

Research progress in application of functional film coatings in the oral multiple-unit pulsatile delivery system

脉冲给药系统(pulsatile delivery system)又名择时释药系统,是根据疾病发作时间规律适时地释放药物的给药系统。相比于单-单元型制剂,多微粒系统具有良好的释放调节性,所以已成为脉冲给药系统新的研究热点。目前多数的口服多微粒脉冲释药系统的释药曲线特征是通过功能性包衣膜实现。所以本文概述了口服多微粒脉冲释药系统中功能性包衣膜的分类及应用进展,重点介绍了包衣膜处方组成对药物释放行为的影响及相应的药物释放机制。

Pulsatile delivery system,also referred as time-controlled release system,can release the active ingredient timely according to the time attack regularity. Compared to the single-unit dosage forms,multiple-unit system has a good regulatory of the release and has become the focus in the pulsatile delivery system. At present,the release curve feature of the oral multiple-unit pulsatile delivery system is mostly achieved by the functional film coatings. Therefore,the application and the categories of the functional film coatings were reviewed. The effect of the coating formulation on the drug release and the corresponding mechanism of the drug release were also discussed in this article.