海昆肾喜胶囊治疗糖尿病肾病98例的临床疗效

Clinical effect of Haikunshenxi capsule in diabetic patients with nephropathy

目的:探讨海昆肾喜胶囊治疗糖尿病肾病患者的临床疗效。方法:回顾性分析我院治疗的196例糖尿病肾病患者的临床资料,根据治疗方法不同分为治疗组和对照组各98例,其中对照组患者采用常规对症治疗,治疗组患者在对照组的基础上加用海昆肾喜胶囊治疗,比较两组患者的临床效果以及治疗前后中医症候积分和各实验指标变化。结果:治疗组患者的总有效率85.71%,显著高于对照组患者65.30%(P<0.05);治疗前两组的中医症候积分均无显著性差异;治疗后治疗组Ⅲ期和Ⅳ期患者的中医症候积分分别为(18.15±3.46)和(37.58±7.95)分,均显著低于对照组患者(P<0.05);治疗前两组患者的各实验指标均无显著性差异,治疗后治疗组患者的尿蛋白(0.85±0.21)g·24 h-1、C-反应蛋白(CRP)(1.03±0.46)μg·L-1、总甘油三酯(TG)(1.04±0.53)mmol·L-1、血肌酐(Scr)(81.8±13.30)μmol·L-1均显著低于对照组患者,治疗组肾小球滤过率(GFR)(56.58±11.27)m L·min-1·1.732 m-2显著高于对照组患者(P<0.05),且两组患者不良反应情况无显著性差异。结论:海昆肾喜胶囊能明显改善患者的中医症候和各实验指标,临床效果显著。

Objective： To investigate the clinical efficacy of Haikunshenxi capsule in patients with diabetic nephropathy. Methods： Clinical data of 196 patients with diabetic nephropathy in our hospital were retrospectively analyzed. Patients were divided into Haikunshenxi capsule and control groups（ n = 98 in each group）,they were treated with conventional symptomatic treatment alone（ control） or combined with Haikunshenxi capsule. Clinical responses,symptom scores and laboratory indicators before and after treatment were compared. Results： The total efficiency of patients in Haikunshenxi group was 85. 71%,and significantly higher than in control patients（ 65. 30%,P〈 0. 05）. Chinese medicine（ TCM） symptoms showed no significant difference in both groups before treatment; after treatment the symptom scores of III and IV patients in Haikunshenxi group were（ 18. 15 ± 3. 46）points,（ 37. 58 ± 7. 95） points,which were significantly lower than those in control group（ P 〈0. 05）. All laboratory indicators had no significant difference between two groups before treatment; after treatment,proteinuria was（ 0. 85 ± 0. 21） g·24 h^- 1,C- reactionprotein（ CRP）（ 1. 03 ± 0. 46） μg·L^- 1,Triglyceride（ TG）（ 1. 04 ± 0. 53）mmol·L^- 1,and Serum creatinin（ Scr）（ 81. 8 ± 13. 30） μmol·L^- 1in Haikunshenxi group,which were significantly lower than those in control group. Glomerular filtration rate（ GFR） level was（ 56. 58 ± 11. 27） m L·min- 1·1. 732 m^- 2in Haikunshenxi group,which was significantly higher than control group（ P〈 0. 05）. Adverse reactions had no significant difference between two groups. Conclusion： Haikunshenxi capsule can significantly improve symptoms and various laboratory parameters in diabetic patients with nephropathy.