奇正青鹏软膏联合丁酸轻化可的松乳膏治疗湿疹临床疗效观察

Evfficacy of Qizheng Qingpeng ointment combined with Hydrocortisome Butyrate cream on treatment of ec-zema

目的：探讨奇正青鹏软膏治疗湿疹的疗效和安全性。方法采用随机开放平行对照试验将98例湿疹患者分为两组，前2周分别给予奇正青鹏软膏＋丁酸轻化可的松乳膏（尤卓儿）与尤卓儿单独外用对比治疗；后2周改为所有患者均给予奇正青鹏软膏＋尤卓儿治疗。结果治疗后第1周、第2周两组患者总有效率分别为：研究组68．52％、87．03％，对照组27．91％、58．13％，经统计学检验研究组总有效率优于对照组（χ2＝14．21、8．99，均P＜0．01）；治疗后第4周两组总有效率分别为：研究组94．44％，对照组90．70％，经统计学检验两组总有效率差异无统计学意义（χ2＝0．11，P＞0．05）。结论奇正青鹏软膏与糖皮质类固醇联合应用治疗湿疹疗效优于单用糖皮质类固醇。

Objective To investigate the effect and safety of Qizheng Qingpeng ointment in the treatment of eczema.Methods Ninety -eight patients of eczema were randomly divided into two groups, who received either Qizheng Qingpeng ointment plus hydrocortisone butyrate cream or only hydrocortisone butyrate cream at the first 2 weeks,and all patients were treated of Qizheng Qingpeng ointment plus hydrocortisone butyrate cream at the further 2 weeds.Results At 1 week and 2 week post-treatment,the efficacy rates were 68.52%,87.03% for the study groups and 27.91%,58.13%for the control groups,the efficacy rate of the study groups was statistically better than that of the control groups （χ2 =14.21,8.99, all P〈0.01 ）;At 4 week post -treatment, the efficacy rates were 94.44%for the study groups and 90.70%for the control groups,the difference of the efficacy rates in the two groups were no statistically significant （χ2 =0.11,P〉0.05） .Conclusion The clinical efficacy of Qizheng Qingpeng oint-ment associated with corticosteriod for treatment of eczema was better than corticosteriod alone.