子痫前期与患者血清镁含量的病例对照研究

Preeclampsia and serum magnesium: a case-control study

目的 探讨子痫前期与患者血清镁含量的关系。方法 采用1∶2病例对照的前瞻性研究方法,选取2011-05～2014-12西安市中心医院39例子痫前期重度患者和78例正常妊娠健康对照者,分别检测其18-22周和30-35周血清镁含量,检测结果运用SPSS10.0统计软件分析结果。结果 子痫前期组和对照组18-22周血清镁含量分别为（1.79±0.18）mg/dl和（2.26±0.37）mg/dl,30-35周血清镁含量分别为（1.73±0.42）mg/dl和（2.04±0.58）mg/dl。子痫前期组血清镁含量在18-22周及30-35周时均显著低于对照组（P〈0.05）。结论 在孕妇妊娠18-22周时检测患者血清镁具有重要的意义,可以作为子痫前期的预测因子之一。

Objective To investigate the relationship between preeclampsia and serum magnesium content. Methods Serum magne- sium content was detected in 39 cases of severe preeclampsia and 78 control subjects at pregnant 18 -22 weeks and 30 -35 weeks with the 1 ： 2 case-control in Xi＇ an Central Hospital from May 2011 to December 2014. The results were analyzed by SPSSI0.0 statistical software. Results The serum magnesium content was significantly lower in preeclampsia group than in control group at 18 - 22 weeks [ （ 1.79 ± 0.18 ） mg/dl vs （2.26 ± 0.37 ） mg/dl, P 〈 0.05 ] and at 30 - 35 weeks [ （ 1.73 ± 0.42 ） mg/dl vs （2.04 ±0. 58 ） mg/ dl, P 〈 0.05 ]. Conclusion Serum magnesium content in preeclampsia patients is very important during the pregnant 18 - 22 weeks, and can be used as one of the predictors of preeclampsia.