不同部位分离的铜绿假单胞菌的耐药性对比研究

Comparative study on drug resistance of pseudomonas aeruginosa isolated from different sites of patients

目的分析住院患者中,铜绿假单胞菌的常见感染部位及相应的耐药情况,为临床的合理用药提供参考依据。方法回顾性分析本院2012年1月至2013年12月分离培养的铜绿假单胞菌的标本分布,并对不同部位分离的铜绿假单胞菌的耐药率进行统计分析。结果铜绿假单胞菌分离率以呼吸道标本最高,占74.1%,其次是中段尿和伤口分泌物。3种标本的铜绿假单胞菌对各种抗菌药物的耐药率差异具有统计学意义(P<0.05)。呼吸道分离的铜绿假单胞菌的耐药率比较高,而伤口分泌物较低。结论铜绿假单胞菌以呼吸道感染最常见,耐药率最高。不同感染部位的铜绿假单胞菌对抗菌药物的耐药率有明显差异,应在临床上用药治疗时予以区别对待。

Objective To analyze the infection sites of pseudomonas aeruginosa（PAE）isolated from patients in hospital,and investigate their drug resistance situation,in order to provide reference information for clinical use of antibiotics rationally.MethodsThe sample distribution of PAE between January 2012 and December 2013 were retrospectively analyzed.And the resistance rates of PAE to antibacterial drugs from different sites of patients were statistically compared.Results The isolation rate of PAE in respiratory tract was the highest,accounting for 74.1%,closely followed by isolation rate in urine and wound secretion.The resistance rate of PAE to antibacterial drugs in these three kinds of specimen is statistically different（P〈0.05）.The resistance rate of PAE is high in respiratory tract,and low in wound secretion.Conclusion The pseudomonas aeruginosa infection is mostly commonly found in respiratory tract,and has the highest drug resistance rate.The choice of antibacterial drug should be made according to the infection sites of patients,because the resistance rate of PAE in different sites of patients is significantly different.