多囊卵巢综合征的性激素、胰岛素抵抗与超声影像相关性分析

The correlation between sex hormones and insulin resistance and ultrasonography in polycystic ovary syndrome

目的探讨多囊卵巢综合征(PCOS)患者血液中性激素及胰岛素抵抗的特征并分析与超声影像之间的相关性。方法对2010年4月至2013年12月来本院进行治疗的120例PCOS患者(PCOS组)及50例健康体检者(对照组)进行超声影像指标检查,包括卵巢间质面积(SA)、卵巢总面积(TA)并计算SA/TA比值,以及检测血液中卵泡生成激素(FSH)、黄体生成激素(LH)、LH/FSH、雌二醇(E2)、睾酮(TESTO)、催乳激素(PRL)。对PCOS组检测空腹血糖(FPG)和空腹胰岛素(FIN),计算稳态模型指数(HOMA-IR)来评估胰岛素抵抗。结果 PCOS组的LH、LH/FSH、TESTO、SA、SA/TA均明显高于对照组,PCOS组的SA、SA/TA与LH、LH/FSH、TESTO、HOMA-IR呈正相关。结论 PCOS患者性激素水平及胰岛素抵抗与超声影像指标具有相关性。

Objective To explore the features of sex hormones and insulin resistance and to analyse the relation between these features and ultrasonographic data in patients with polycystic ovary syndrome（PCOS）.Methods 120 patients with PCOS diagnosed and treated in hospital from April 2010 to December 2013 were enrolled as PCOS group,and 50 healthy persons as control group,in both groups,ovarian stromal area（SA）,ovarian total area（TA）and SA/TA ratio were measured by ultrasonography,and serum levels of follicle stimulating hormone（FSH）,luteinizing hormone（LH）,LH/FSH ratio,estradiol（E2）,testosterone（TESTO）,and prolactin（PRL）were assayed.Fasting plasma glucose（FPG）and fasting insulin（FIN）were measured,and homeostasis model assessment for insulin resistance（HOMA-IR）was calculated in the PCOS group.Results the serum levels of LH,LH/FSH ratio,TESTO,SA,and SA/TA ratio in the PCOS group were higher than that of the control group.SA and SA/TA ratio were correlated positively with LH,LH/FSH,TESTO,and HOMA-IR in the PCOS group.Conclusion sex hormones and insulin resistance were correlated with ultrasonographic data in the PCOS patients.