225例闭经患者染色体核型分析及临床意义

Chromosome karyotypte and clinical analyse in 225 amenorrheas

目的分析原发闭经和继发闭经患者的染色体异常情况并探讨其临床意义。方法抽取患者外周血培养,制备染色体,采用G显带分析。结果 225例原发闭经和继发闭经患者,共检出异常核型63例,占28%。其中,原发闭经患者148例,异常核型55例,占37.16%。继发闭经患者77例,核型异常8例,占10.39%。结论染色体异常是导致原发闭经和继发闭经的主要原因,对闭经患者进行染色体检查,明确闭经原因,及早对症治疗有重要意义。

Objective To analyse the suffer′excrescent circumstance in chromosome who are primary amenorrhea or secondary amenorrhea and inquiry its clinical meaning.Methods Take out patients′peypheyal vein blood to cultuve,the chromosome was prepared,G band was analysed.Results primary amenorrhea or secondary amenorrhea suffer totally 225,there were 63 with chromosom abnormal karyotyptes which occupies 28%;Among 148 the patiens of primary amenorrhea,chromosom abnormal karyotyptes were 55 examples which occupies 37.16%,secondary amenorrhea is 77 examples,chromosom abnormal karyotyptes were 8examples which occupies 10.39%.Conclusion Chromosome abnormals are the main cause of primary amenorrhea and secondary amenorrhea.in patients with chromosom analyse,to kncw the cause of amenorrhea,early symptomatic treatment is important.