红细胞分布宽度、胱抑素C和脂蛋白(a)与冠心病病变程度的相关性研究

Correlation between RDW,CysC,and LP(a) with lesion severity of coronary heart disease

目的探讨红细胞分布宽度（RDW）、胱抑素C（Cys C）和脂蛋白（a）[LP（a）]水平与冠心病病变程度的相关性。方法选择2012年3月至2014年9月本院心内科收治经冠状动脉造影确诊的冠心病患者130例,根据造影结果将冠心病患者分为单支病变组、双支病变组、多支病变组;根据冠心病患者的Gensini积分,分为1-30分组、31-60分组及〉60分组;另选择同期住院的冠状动脉造影正常者45例为对照组,分别检测各组RDW、Cys C和LP（a）水平,并将各组RDW、Cys C、LP（a）的检测结果进行比较分析。结果冠心病组RDW、Cys C及LP（a）水平明显高于正常对照组,差异有统计学意义（P〈0.05）。随着冠脉病变支数和Gensini积分的增加,RDW、Cys C、LP（a）大致呈增高趋势,相关分析显示,RDW、Cys C、LP（a）与Gensini积分均呈正相关。结论 RDW、Cys C、LP（a）水平在冠心病患者中明显高于正常对照组,与冠心病病变程度密切相关,均可能是冠脉病变程度新的预测因子。

Objective To study the correlation between the red cell distribution width（RDW）,cystatin C（Cys c）and lipoprotein（a）[LP（a）]with the lesion severity of coronary heart disease.Methods 130 cases of coronary heart disease（CHD）definitely diagnosed by coronary arteriography in the cardiology department of our hospital from March 2012 to September 2014 were selected.The subjects were divided into the single-vessel lesion group,double-vessel lesion group and multiple-vessel lesion group according to the coronary arteriographic results;furthermore the subjects were divided into the 1-30 points group,31-60 points group and the60points group according to the Gensini scores;other contemporaneous 45 individuals of normal coronary arteriography were selected as the control group.RDW,Cys C and LP（a）levels were detected in each group and the detection results were performed the comparative analysis.Results The RDW,CysC and LP（a）levels in the CHD group were significantly higher than those in the control group,the differences were statistically significant（P〈0.05）.With the increase of coronary lesion vessels number and Gensini score,the RDW,CysC and LP（a）levels showed roughly increasing trend,the correlation analysis showed that the RDW,CysC and LP（a）were positively correlated with Gensini scores.Conclusion The RDW,CysC and LP（a）levels in the patients with CHD are higher than those in the normal control group,which are closely related with the lesion severity of CHD and may be the new predictors of coronary lesion severity.