高龄老年女性股骨颈骨密度独立相关因素的研究

Independent factors associated with bone mineral density of the femoral neck in the elderly women

目的为了筛选高龄老年(≥80岁)女性股骨颈骨密度(FNBMD)的独立相关因素。方法对332例高龄老年女性进行FNBMD、血液生化、骨代谢和生殖激素等指标的检测,运用多元回归分析方法筛选高龄老年女性股骨颈骨密度的独立相关因素。结果高龄老年女性FNBMD的独立相关因素有体重指数(β=0.008,P<0.001)、睾酮(β=0.029,P<0.001)、慢性阻塞性肺疾病(β=-0.039,P<0.05)、年龄(β=-0.005,P<0.05)和空腹血糖(β=0.016,P<0.05)。结论维持合理的体重指数、睾酮和空腹血糖水平,积极防治慢性阻塞性肺疾病,可能是提高高龄老年女性FNBMD的重要方法。

Objective To screen the independent factors associated with bone mineral density of the femoral neck（ FNBMD） in women aged 80 and over. Methods A total of 332 elderly women were recruited. FNBMD,serum biochemistry,bone turnover markers,and sex hormones were measured. Univariate analysis and multivariate regression analysis were applied to discover the independent factors associated with FNBMD. Re sults The independent factors associated with FNBMD included body mass index（ β = 0. 008,P〈0. 001）,testosterone（ β = 0. 029,P〈0. 001）,chronic obstructive pulmonary disease（ β =- 0. 039,P〈0. 05）,age（ β =- 0. 005,P〈0. 05）,and glucose（ β = 0. 016,P〈0. 05）. Conclusion The probable ways to increase FNBMD in elderly women are to keep a proper body mass index,the concentration of serum testosterone,and serum glucose,and to prevent and cure chronic obstructive pulmonary disease.