探讨大陆地区绝经后妇女骨质疏松症自我筛查工具的临床应用价值

Evaluation of the clinical value of osteoporosis screening tool Chinese in postmenopausal women in China's Mainland

目的评价中国大陆地区绝经后妇女骨质疏松症自我筛查工具（osteoporosis screening tool Chinese,OSTC）临床应用价值。方法 2013年11月～2014年3月纳入292名50周岁以上绝经后妇女,应用双能X线骨密度仪测量受试者腰椎及左侧股骨近端骨密度数据,利用体重和年龄计算OSTC指数,并进行比较。结果 OSTC指数与腰椎及骨股颈骨密度呈正相关（r=0.430,r=0.623,P〈0.001）;按两级风险程度分类界值判定,OSTC的敏感度92.7%,特异度为37.1%,ROC曲线下面积（AUC）及其95%CI分别为0.760（0.697,0.823）。结论 OSTC指数与骨密度呈正相关,敏感度高,作为绝经后妇女骨质疏松的早期筛查工具,有较高的临床应用价值。

Objective To evaluate the clinical value of osteoporosis screening tool Chinese（ OSTC） in postmenopausal women in China's Mainland. Methods A total of 292 over 50 years old women were recruited from November 2013 to March 2014. Bone mineral density of the lumbar spine and the left femoral neck was examined using DXA. OSTC risk indexes of each subject were calculated based on their weight and age,and were then compared. Re sults The bone mineral density of the lumbar spine and the left femoral neck was positively correlated with OSTC indexes（ r = 0. 430,r = 0. 623,P〈0. 001）. According to the two risk levels,OSTC indexes could diagnose osteoporosis with the sensitivity of 92. 7% and with the specificity of 37. 1%. The area under ROC curve was 0. 760,and the 95% confidence interval was from 0. 697 to 0. 823. Conclusion OSTC index is positively correlated with bone mineral density,with high sensitivity. It can be used as an early screening tool for postmenopausal osteoporosis and has a high clinical application value.