期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

mTOR对免疫应答的调节

下载PDF
导出
摘要 mTOR是雷帕霉素在哺乳动物上的作用靶点,它是一种进化上保守的丝氨酸/苏氨酸激酶,在生长因子、氨基酸和能量的集中信号传导中起着核心作用。它的活化作用能够调节新陈代谢,所以在细胞新陈代谢需求以及细胞功能之间也提供了重要联系。
作者 曾静 李伟毅
机构地区 上海交通大学医学院
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2015年第7期996-1001,共6页 Chinese Journal of Immunology
关键词 MTOR 免疫应答 活化作用 免疫研究 细胞分化 免疫微环境 免疫功能 细胞新陈代谢 生长因子 信号传导
分类号 R392 [医药卫生—免疫学]
  • 相关文献

参考文献37

  • 1Delgoffe GM, Powell JD. mTOR:taking cues from the immune mi- [ J ]. Immunology, 2009,127 (4) :459-465.
  • 2Vezina C, Kudelski A, Sehgal SN. Raparnycin ( AY-22,989 ), a new antifungal antibiotic[ J]. Antibiot, 1975,28 (10) :721-726.
  • 3Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factorsand stress [ J]. Mol Cell ,2010,40:310-322.
  • 4Brugarolas J, Lei K, Hurley RL,et al. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex [ J ]. Genes Dev,2004,18 ( 23 ) :2893-2904.
  • 5Yu L, MePhee CK, Zheng L, et al. Termination of autophagy and reformation of lysosomes regulated by mTOR [ J]. Nature,2010, 465 ( 7300 ) :942-946.
  • 6Lee K, Gudapati P, Dragovie S, et al. Mammalian target of rapamycin protein complex 2 regulates differentiation of Thl and Th2 cell subsets via distinct signaling pathways [ J ]. Immunity, 2010,32(6) :743-753.
  • 7Safford M, Collins S, Lutz MA, et al. Egr-2 and Egr-3 are negative regulators of T cell activation [ J ]. Nat Immunol, 2005,6 ( 5 ) : 472-480.
  • 8Allen A, Zheng Y, Gardner L, et al. The novel eyelophilin binding eompound,sanglifehrin A, disassociates G1 cell cycle arrest from tolerance induction [ J ]. Immuno1,2004,172 ( 8 ) :4797-803.
  • 9Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing [ J ]. Nat Rev Mol Cell Biol,2010,12( 1 ) :21-35.
  • 10Yu L, McPhee CK, Zheng L, et al. Termination of autophagy and reformation of lysosomes regulated by mTOR [ J ]. Nature, 2010, 465 ( 7300 ) :942-946.

二级参考文献38

  • 1韩璐,尤庆山,曲学龄,王化丽.HIF-1α基因转染宫颈癌细胞对VEGF表达的影响[J].中国实用妇科与产科杂志,2006,22(4):287-288. 被引量：4
  • 2Sarbassov D Guertin DA, Ali SM, et al. Phosphory- lation and reg- ulation of Akt/PKB by the rictor - mTOR complex. Science, 2005, 307(5712) : 1098 -1101.
  • 3Guertin DA, Sabatini DM. An expanding role for mTOR in cancer. Trends Mol Med, 2005, 11(8): 353-361.
  • 4Sarbassov DD, Guertin DA, Ali SM, et al. Phosphorylation and regulation of Akt/PKB by the rictor - mTOR complex. Science, 2005, 307(5712) : 1098 - 1101.
  • 5Jung CH, Ro SH, Cao J, et al. mTOR regulation of autophagy. FEBS Lett ,2010, 584 (7) : 1287 - 1295.
  • 6Vignot S, Faiver S, Aguirre D, et al. mTOR targeted therapy of cancer with rapamycin derivatives. Annals of Oncology,2005,16: 525 - 537.
  • 7Adjei AA, Hidalgo M. Intracellular signal transduction pathway proteins as targets for cancer therapy. J Clin Onco1,2005,23:5386 - 5403.
  • 8Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes&Development ,2004,18 : 1926 - 1945.
  • 9Charest PG. A Ras signaling complex controls the RasC - TORC2 pathway and directed cell migration. Dev Cell, 2010, 18 : 737 - 749.
  • 10Hara K. Regulation of elF -4E BP1 phosphorylation by mTOR. Bi- ol Chem, 1997,272:26457 - 26463.

共引文献24

中国免疫学杂志
2015年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部