(R)-2-羟基-4-苯基丁酸乙酯合成工艺研究进展

Process on Synthesis Technology of (R)-2-Hydroxyl-4-phenyl Ethyl Butyrate

(R)-2-羟基-4-苯基丁酸乙酯(R-HPBE)是一种重要的医药中间体,在合成普利类药物中具有非常广阔的应用前景。本文综述了采用生物法和化学法等制备R-HPBE的工艺,并对以上技术路线特点进行讨论,得出不对称催化氢化合成R-HPBE是一种绿色生产工艺。

（R） -2 - hydroxyl -4 - phenyl ethyl butyrate （R - HPBE ） is a kind of important pharmaceutical intermediates, which has a very broad application prospects in the synthesis of captopril drugs. This paper illustrates the preparation route of R - H.PBE and its characteristics by biological and chemical methods, with asymmetric that catalytic hydrogenation synthesis of R- HPBE is the kind of green process.