血清CA724、CEA、TNF-α联合检测对进展期胃癌诊疗的临床价值

Clinical value of combined detection of serum CA724, CEA and TNF-α for advanced gastric cancer

目的 探讨血清糖链抗原724（CA724）、癌胚抗原（CEA）、肿瘤坏死因子-α（TNF-α）联合检测在进展期胃癌（AGC）诊断、疗效判定及病情监测中的临床价值.方法 采用化学发光法检测20例AGC患者（A组）、20例良性胃病患者（B组）、20例正常人（C组）血清CA724、CEA、TNF-α的含量,比较A、B、C组受试者血清CA724、CEA、TNF-α含量的差异;检测并比较A组患者手术治疗前后外周静脉血、门静脉血中CA724、CEA、TNF-α含量的差异.结果 A组患者血清CA724、CEA、TNF-α的含量明显高于B、C组,差异有统计学意义（P＜0.05）;A组患者手术治疗后CA724、CEA、TNF-α含量较手术治疗前明显下降,术后1个月CA724、CEA、TNF-α含量略有上升,各时间点差异有统计学意义（P＜0.05）.结论 多数AGC患者血清CA724、CEA、TNF-α含量明显升高,血清CA724、CEA、TNF-α的联合检测有助于AGC的诊断、疗效判定及病情监测.

Objective To explore the clinical value of combined detection of serum carbohydrate antigen 724 （CA724）,carcinoembryonic antigen （CEA）,and tumor necrosis factor-α （TNF-α） for the diagnosis,assessment of curative effect,and illness monitoring for advanced gastric cancer （AGC）.Methods Serum levels of CA724,CEA and TNF-α were measured by the methods of chemiluminescence and compared in 20 patients with AGC （Group A）,20 patients with benign gastric disease （Group B）,and 20 healthy adults （Group C）.Also,serum levels of CA724,CEA and TNF-α in peripheral blood as well as in portal vein were measured and compared before and after surgical treatment in patients of group A.Results The serum levels of CA724,CEA and TNF-α in patients of group A were significantly higher than groups B and C （P 〈 0.05）.In addition,the serum levels of CA724,CEA and TNF-α in patients of group A were decreased after surgical treatment and increased slightly after one month （P 〈 0.05）.Conclusions The serum levels of CA724,CEA and TNF-α in most patients of AGC are significantly elevated and the combined detection of serum CA724,CEA and TNF-α contributes to the diagnosis,assessment of curative effect,and illness monitoring for AGC.