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帕金森病患者血尿酸水平分析 被引量:2

The Levels of Blood Uric Acid in Parkinson's Disease
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摘要 目的:观察帕金森病(PD)患者血尿酸水平。方法:比较71例帕金森病患者(PD组)和79例健康体检者(对照组)的血尿酸水平,并比较早、中、晚期及不同性别PD患者的血尿酸水平。结果:PD组血尿酸水平低于健康对照组(P<0.05),男性和女性PD组血尿酸水平均低于对应的健康对照组(P<0.05);男性PD患者血尿酸水平低于女性PD患者血尿酸水平(P<0.05);早期和中期女性PD患者血尿酸水平间差异无统计学意义(P>0.05),但均高于晚期患者,差异具有统计学意义(P<0.05);在男性PD患者,随着病情加重,血尿酸逐渐降低,各期比较差异有统计学意义。结论:血尿酸水平可能是帕金森病的重要生物学指标之一,并且存在性别差异。 Objective:To discuss the blood uric acid levels of patients with Parkinsonˊs disease. Methods:The level of blood uric acid was compared between 71 PD patients( PD group)and 79 healthy patients( control group ). The PD disease progression was assessed by Hoehn-Yahr( H-Y ) scale. PD group was divided into 3 subgroups according to H-Y scales:earlier stage,mid-term stage and terminal stage. The level of blood uric acid was compared among 3 subgroups and between differ-ent genders. Results:The average level of blood uric acid in PD group was significantly lower than that in control group( P﹤0 . 05 ). The blood uric acid levels of male and female in PD group were sig-nificantly lower than their counterparts in control group. The blood uric acid level of male PD patients was higher than that of female PD patients( P﹤0 . 05 ). There were no significant difference in blood uric acid level between female PD patient in earlier stage and in mid-term stage( P﹥0 . 05 ),but blood uric acid level in earlier stage,mid-term stage was significantly higher than that in terminal stage( P﹤0. 05). In male PD patients,as the disease got worse,blood uric acid level was gradually decreased, and there was statistical significance between different stages( P﹤0 . 05 ). Conclusion:Blood uric acid level may be an important biological index of Parkinson disease.
作者 马兆雷 焦玲
出处 《贵阳医学院学报》 CAS 2015年第8期867-869,共3页 Journal of Guiyang Medical College
关键词 帕金森病 氧化应激 血尿酸 多巴胺能神经元 Hoehn-Yahr分期 Parkinsonˊs disease oxidative stress blood uric acid dopaminergic neuron Hoehn-Yahr stage
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