绝经后期干眼的研究进展

Current progress in postmenopausal women with dry eye

干眼是常见的眼表疾病。近年来研究认为眼表改变、基于免疫的炎症反应、细胞凋亡及性激素水平降低均可导致眼表上皮细胞损伤及泪液质量下降。绝经后期妇女因卵巢功能减退、激素水平降低,导致泪膜结构和功能异常,促使干眼症的发生。本文就绝经后期干眼的眼表改变、发病机制、治疗进展三个方面进行综述。

Dry eye is one of the most frequently ocular surface diseases.Recent researches found that many reasons caused decrease of ocular surface damage and the quality of tears,such as the change of ocular surface,immuno-inflammatory responses,apoptosis and the reduction of sex hormone.It is reported that the decline of ovarian function and hormone level in postmenopausal women which leads to abnormal structure and function of tear film is more likely to develop dry eye.In this paper,the ocular surface,pathogenesis and progresses of treatment on postmenopausal women with dry eye are reviewed.