美浮特~皮肤抗菌液治疗部队足癣患者的疗效研究

Efficacy and safety of Meifute~ antifungal solution in the treatment of tinea pedis cases from troops

目的观察美浮特皮肤抗菌液治疗足癣的的临床疗效和安全性。方法 2014年7月,选取部队足癣患者212例入组接受治疗,其中解放军三军仪仗队（仪仗队组）108例,北京武警某部（武警组）104例。疗程：一般选用单次治疗,一次性浸泡2 h。对于部分伴有鳞屑角化或伴发水疱的足癣,可增加1~2次治疗,每次浸泡时长仍为2 h,使用间隔14 d。分别于首次使用皮肤抗菌液治疗后1周、2周、4周时进行观察、随访,并记录不良事件。对部分病例,在治疗6个月后观察足癣的复发率。结果最终完成治疗和随访的有效病例有206例（仪仗队组104例,武警组102例）。第4周随访,总有效率为95.6%（197/206）,其中痊愈率78.2%（161/206）、显效率17.5%（36/206）,总真菌学清除率为95.1%。其中,仪仗队组第4周总有效率96.1%（100/104）,痊愈81.7%（85/104）;武警组第4周总有效率95.1%（97/102）,痊愈率74.5%（76/102）。安全性：不良反应均表现为局部症状,如轻度疼痛（51/212）,均于治疗结束后即得到缓解;局部皮肤水肿（12/212）,治疗结束后2 h内均自行缓解。未发现全身性不良反应。复发率：治疗后6个月可随访的156例中,总复发率8.97%（14/156）,其中仪仗队组复发率3.06%（3/98）,武警组复发率为18.97%（11/58）。患者满意度评价,总满意度为95.32%。结论美浮特皮肤抗菌液治疗足癣临床疗效显著、安全性好,尤其适用于治疗需求迫切,需要短时、便捷、快速起效治疗方法的足癣人群。

Objective To evaluate efficacy and safety of Meifute antifungal solution in treating tinea pedis cases from troops.Methods Generally,a single-session soak in Meifuteantifungal solution for up to120-minute long was the suggested treatment of tinea pedis.As for some tinea pedis cases with hyperkeratosis or blisters,repeated treatment of one or two sessions at 14 day intervals might be recommended.Effect and safety evaluation was performed at week one（ V1）,week two（ V2）,and week four（ V3） after initial treatment.Result Finally there were 206 cases of tinea pedis being enrolled into this study,including 104 cases of group Honour Guard（ i.e.group H.G.） and 102 cases of group Armed Police（ i.e.group A.P.）.At week four（ V3）,overall effective rate was 95.6%（ 197/206）,the cure rate was 78.2%（ 161/206）,overall fungal clearance rate was 95.1%.Group H.G.had an effective rate of 96.1%（ 100/104） and a cure rate of 81.7%（ 85/104）.Group A.P.got an effective rate of 95.1%（ 97/102） and a cure rate of 74.5%（ 76/102）.There were only several cases of local side effects including mild pain（ 51 / 212） that could relieved once soak finished,and local mild edema（ 12 / 212） that self-subsided during 2 hours after soak. Follow-up of 6 months later revealed a recurrence rate of 8.97%（ 14 / 156）.The recurrence rates of Group H. G. and Group A. P. were 3. 06%（ 3 / 98） and 18. 97%（ 11 / 58）,respectively. The comprehensive satisfactory rate of patient reached up to 95.32%.Conclusion Meifuteantifungal solution has showed good efficacy and is well tolerated in treating tinea pedis.It is especially recommended to be used in the patients who requiring a fastly and rapidly responsed therapeutic method to relieve their symptons and signs of tinea pedis within a short duration.