心肝胃同治方促血管新生作用的研究

Effects of xinganwei tongzhifang on neovascularization of myocardial infarction rats

目的探讨心肝胃同治方对心肌梗死模型大鼠心肌梗死面积和血管内皮生长因子的影响。方法将已造模成功的大鼠,随机分为假手术组,模型组,消心痛组,心肝胃同治高、低剂量组。各用药组分别对应性给予心肝胃同治方及消心痛水溶液,其他组给予等量蒸馏水,每天灌胃1次,连续用药2周,处死大鼠,检测心肌梗死大鼠的心肌梗死面积和血管内皮生长因子。结果心肝胃同治方高低剂量组心肌梗死面积优于消心痛组(P<0.05)。心肝胃同治高、低剂量组及消心痛组血清中血管内皮生长因子含量明显高于模型组(P<0.05),且心肝胃同治高剂量组优于低剂量组、消心痛组(P<0.05)。结论心肝胃同治方对心肌梗死具有明确的治疗作用,其机制与促血管新生有关。

Objective To observe the Effect of Xinganwei Tongzhifang on area of myocardial infarction and VEGF. Methods Myocardium of infarcted rats model were made by Wistar rats. They were divided randomly into four groups which were model group, ID group,Xinganwei Tongzhi high and low dose groups. Sham operation group was made at the ~same time. Subsequently drug treatment groups were administrated with ID water solution and Xinganwei Tongzhi water solution. The model group and sham group were treated with distilled water with the equal volume. Rats were treated once every day by intragastric administration. After 2 weeks continuously, executed the rats. The content of serum VEGF and area of myocardial infarction were evaluated. Results The area of myocardial infarction of High-dose group and low-dose group were better than ID group （ P 〈 0. 05 ）. The VEGF content of All treatment groups were higher than that of model group（ P 〈 0. 05 ）. High-dose group was better than low-dose group and ID group（ P 〈 0.05 ）. Conclusion Xinganwei Tongzhifang had therapeutic action on myocardi- al infarction rats. The mechanism was related to angiogenesis.