氟哌噻吨美利曲辛治疗老年心肌梗死后抑郁的疗效观察

Effect of Flupentixol and Melitracen on depression in elderly patients with myocardial infarction

目的观察氟哌噻吨美利曲辛(黛力新)治疗老年心肌梗死后抑郁的疗效以及对心肌梗死后患者预后的影响。方法将60例心肌梗死伴抑郁障碍的老年患者随机分为治疗组和对照组各30例,对照组常规给予扩冠、抗凝、抗血小板聚集、他汀类药物治疗。治疗组在对照组治疗基础上加用黛力新。2周为1个疗程。2组均给予解释安慰等心理治疗。结果治疗组心律失常、梗死后心绞痛、心功能不全、心源性死亡的发生率小于对照组,心功能状态优于对照组,抑郁状态的改善明显优于对照组,差异均有统计学意义(P<0.05)。结论黛力新对心肌梗死后老年患者的抑郁症状有一定疗效,能明显改善心肌梗死患者的预后。

Objective To investigate the Flupentixol and melitracen （Dailixin） after myocardial infarction in elderly efficacy and depression in patients after myocardial infarction prognosis. Methods 60 elderly patients with acute myocardial infarction with depression were randomly divided into treatment group and control group, 30 cases in control group were treated with expanded crown, anticoagulation, anti platelet aggregation, statin therapy. The treatment group was treated with Flupentixol and melitracen on the basis of the control group. 2 weeks for 1 courses. 2 groups were treated with psychotherapy. Results In the treatment group, the incidence of arrhythmia, angina, heart failure, cardiac death, and death in the treatment group was less than the control group, and heart function state is better than the control group, the improvement of depressive state was also significantly better than the control group, the difference was statistically significant （P 〈 0. 05）. Conclusion The effect of Flupentixol and melitracen on the treatment of depression after myocardial infarction is significant, and it can significantly im- prove the prognosis of patients with myocardial infarction.