喜炎平注射液对人鼻病毒感染小鼠的抗病毒作用研究

Study on the antiviral effect of mice infected by Xiyanping injection of human rhinovirus

目的观察喜炎平注射液对人鼻病毒致小鼠感染的抗病毒作用。方法采用人鼻病毒感染小鼠作为模型,测定不同浓度喜炎平注射液对感染小鼠病死率及平均生活日的影响;测定其对感染小鼠气管—肺脏匀浆中的病毒滴度的影响,观察其抗病毒的能力。结果在观察的时间内,喜炎平注射液中剂量组与模型组比较,可显著减少病死率;与模型组相比,喜炎平可显著延长动物平均生存时间;喜炎平不同剂量组对病毒感染小鼠的肺脏病变均有不同程度的改善作用;喜炎平注射液可明显降低气管—肺脏组织匀浆中病毒滴度。结论喜炎平注射液具有抗人鼻病毒的治疗作用,在体内可有效抑制人鼻病毒增殖,能减轻受试动物呼吸道病变,提高存活率,不良反应很低,为进一步临床推广应用提供了实验依据。

Objective Observation of Xiyanping injection induced antiviral effect on human rhinovirus infection in mice. Methods Mice infected with human rhinovirus using different concentrations of Xiyanping Injection. The mortality rate, the average survival time, viral titer in mice trachea -lung homogenate and anti-virus ability of mice was observed. Results Compared with model group, Xiyanping injection can significantly reduce the mortality of mice, and prolong the average survival time. And it also can significantly reduce the virus titer in the trachea and lung tissue homogenate. Conclusion Xiyanping in- jection has antiviral effect on human rhinovirus, can effectively inhibit the proliferation of the virus,improve the survival rate.