维甲酸与亚砷酸双诱导结合化疗治疗急性早幼粒细胞白血病的临床效果

Clinical effect of double induction of retinoic acid and arsenious acid combined chemotherapy in the treatment of acute promyelocytic leukemia

目的 观察维甲酸与亚砷酸双诱导结合化疗治疗急性早幼粒细胞白血病的临床效果。方法 选取2011年1-10月本院收治的急性早幼粒细胞白血病患者50例,按随机数字表法将其分成实验组25例,对照组25例。实验组应用维甲酸与亚砷酸双诱导及化疗方案治疗,对照组应用维甲酸诱导结合化疗治疗,比较两组的临床效果和不良反应发生情况。结果 实验组的高白细胞血症持续时间为（10.21±3.63）d,完全缓解（CR）率为96.0%,3年内死亡率为4.0%,达CR时间为（30.21±5.31）d,对照组分别为（16.21±5.32）d、88.0%、12.0%、（44.62±6.32）d,观察组的高白细胞血症持续时间短于对照组,CR率高于对照组,3年死亡率低于对照组,达CR时间短于对照组（P〈0.05）。两组的高白细胞、骨髓抑制、心功能异常等不良反应发生率,差异无统计学意义（P〉0.05）。结论 维甲酸与亚砷酸双诱导结合化疗治疗急性早幼粒细胞白血病的效果满意,值得临床进一步推广应用。

Objective To observe the clinical effect of double induction of retinoie acid and arsenious acid combined chemotherapy in the treatment of acute promyelocytic leukemia. Methods From January to October in 2011,50 patients with acute promyelocytic leukemia admitted into our hospital were selected and evenly divided into experimental group and control group according to the random number table method.In experimental group,double induction of retinoic acid and arsenious acid combined chemotherapy was applied,while in control group,induced retinoic acid combined with chemotherapy was adopted.The clinical effect and incidence of adverse reaction between two groups was compared respectively. Results In experimental group,duration time of high white blood cell disease was （10.21±3.63） d,the complete remission （CR） rate was 96.0% and mortality rate within 3 years was 4.0%,the time of achieving CR was （30.21± 5.31） d.These indexes in control group was （16.21±5.32） d, 88.0%,12.0% and （44.62±6.32） d respectively.In comparison with the control group,the duration time of high white blood cell disease was shorter, CR rate was higher, mortality rate within 3 years was lower,time of achieving CR was shorter （P〈0.05）.Incidence rate of adverse reactions including high white blood cell,myelosuppression,and abnormal cardiac function and so on between two groups,and there was no sta- tistical difference （P〉0.05）. Conclusion double induction of retinoic acid and arsenious acid combined chemotherapy in the treatment of acute promyelocytic leukemia can obtain a satisfactory effect,which is worthy of further promotion and application in clinic.