脑血栓应用阿片受体拮抗剂的临床疗效研究

Clinical research on treating cerebral thrombosis with opioid receptor antagonists

目的:研究脑血栓应用阿片受体拮抗剂的临床疗效。方法:对照组在基础治疗基础上应用复方丹参注射液,治疗组在基础治疗基础上应用阿片受体拮抗剂代表药物盐酸纳洛酮注射液。治疗结束后比较两组疗效、起效时间、神经功能变化情况。结果:治疗组总有效率90.6%,显著高于对照组的79.3%(P<0.05)。治疗组药物起效时间显著优于对照组(P<0.05)。两组治疗前NIHSS评分无显著差异(P>0.05),治疗后均显著好于治疗前(P<0.05),治疗组神经功能恢复幅度显著优于对照组(P<0.05)。两组治疗期间均无显著不良反应诱发。结论:脑血栓应用阿片受体拮抗剂疗效确切,安全性好。

Objective：To study clinical effect of opioid receptor antagonist on cerebral thrombosis. Methods：the control group was treated with Compound Danshen Injection more than basic treatment, and the research group was treated with opioid antagonists.After the treatment, the effect,the onset time and the nerve function in the two groups were compared.Results：the total efficiency in the study group was 79.25%,significantly higher than that in the control group （P〈0.05）. Clinical effect in the study group was significantly better （P 〈0.05）.The score of NIHSS before treatment was not significantly different before treatment （P〈0.05）,and the recovery of neurological function in the study group was significantly better than that in the control group （P〈0.05）, after treatment. No significant adverse reactions were induced in the two groups. Conclusion：Clinical effects of opioid receptor antagonist is effective and safe in cerebral thrombosis.