超声药物透入疗法防治卡培他滨相关性手足综合征35例

Prevention and treatment of 35 cases with capecitabine hand-foot-related syndrome by ultrasound drug penetration therapy

目的:观察超声药物透入疗法预防及治疗卡培他滨所致手足综合征(hand foot syndrom e,HFS)的疗效。方法:选取卡培他滨化疗患者共35例,35例均为经病理学或细胞学确诊的乳腺癌、结肠癌、胃癌患者。随机分为试验组18例和对照组17例。卡培他滨每日量为2500 mg/m2,分2次口服,连用14 d,休息7 d,21 d为1个周期。预防组18例,化疗同时运用超声药物透入仪导入维生素B6注射液,隔日1次。对照组17例,化疗同时给予维生素B6口服至化疗结束。结果:试验组18例患者中3例发生Ⅰ级手足综合征,发生率为16.7%,对照组手足综合征发生率为44.4%,两者有显著性差异(P<0.05)。结论:超声药物透入疗法可有效防治卡培他滨化疗所致手足综合征。

Objective：To investigate the effects of prevention and treatmentof ultrasound therapy drug penetration on capecitabine induced hand-footsyndrome （hand footsyndrome e, HFS） [1] . Methods：35 cases with capecitabine chemotherapy confirmed by pathology＆amp;nbsp;or cytology of breastcancer, colon cancer, stomach cancer were selected and randomly divided into an experimental group with 18 cases and a control group with 17 cases. The amountof capecitabine was 2500 mg/m2, twice orally, 14 days continuously, rest7 days, 21 days for a p eriod.18 pa tients in the prevention group were treated with ultrasound dru g pe netration i nstrumenti mported vi tamin B6 i njection, every other day, while 17 cases in the control group were treated with vitamin B6 oral chemotherapy until the end of chemotherapy. Results：3 cases among 18 patients in the experimental group occurredⅠgrade hand-footsyndrome, the rate was 16.7%, while thatin the control group hand-footsyndrome was 44.4%with significantdifference （P〈0.05）.Conclusion：Ultrasound drug penetration therapy can effectively control capecitabine chemotherapy induced hand-footsyndrome.