厄贝沙坦片联合盐酸贝尼地平片治疗高血压肾病的临床疗效

Effect of irbesartan and benidipine hydrochloride in treating hypertensive nephropathy

目的探讨厄贝沙坦片联合盐酸贝尼地平片治疗高血压肾病的临床疗效。方法选取2011年1月—2014年1月魏县人民医院收治的高血压肾病患者132例,采用随机数字表法将患者分为厄贝沙坦组(49例),贝尼地平组(43例),联合治疗组(40例)。厄贝沙坦组患者予以厄贝沙坦片治疗;贝尼地平组患者予以盐酸贝尼地平片治疗;联合治疗组患者予以厄贝沙坦片联合盐酸贝尼地平片治疗。观察3组患者治疗前后血压、肾功能〔24h尿蛋白定量、血肌酐(Scr)、血尿素氮(BUN)、内生肌酐清除率(Ccr)〕及不良反应发生情况。结果治疗前3组患者收缩压、舒张压、24h尿蛋白定量、Scr、BUN、Ccr比较,差异无统计学意义(P>0.05);治疗后3组患者收缩压、舒张压、24h尿蛋白定量、Scr、BUN、Ccr比较,差异有统计学意义(P<0.05);联合治疗组患者收缩压、舒张压、24h尿蛋白定量、Scr、BUN低于厄贝沙坦组和贝尼地平组,Ccr高于厄贝沙坦组和贝尼地平组,差异有统计学意义(P<0.05);3组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论厄贝沙坦联合贝尼地平治疗高血压肾病的临床疗效显著,可改善患者临床症状,且不良反应小。

Objective To explore the effect of irbesartan and benidipine hydrochloride in treating hypertensive ne-phropathy. Methods A total of 132 patients with hypertensive nephropathy were selected in the People＇s Hospital of Wei Coun-try from January 2011 to January 2014,according to the random number table,they were divided into irbesartan group（49 ca-ses）,benidipine group（43 cases）,combined treatment group（40 cases）. Irbesartan group were given irbesartan treatment, benidipine group were given benidipine hydrochloride treatment,combined treatment group were given irbesartan and benidipine hydrochloride treatment. Before and after treatment,blood pressure,renal function〔24 hour urinary protein quantity,serum creatinine（Scr）,blood urea nitrogen（BUN）,endogenous creatinine clearance rate（Ccr）〕and incidence of adverse reac-tions were compared. Results Before treatment,systolic pressure,diastolic blood pressure,24 hour urinary protein quantity, Scr,BUN,Ccr showed no significant differences in the three groups（P ﹥ 0. 05）;after treatment,systolic pressure,diastolic blood pressure,24 hour urinary protein quantity,Scr,BUN,Ccr showed significant differences in the three groups（ P ﹤0. 05）;systolic pressure,diastolic blood pressure,24 hour urinary protein quantity,Scr,BUN of combined treatment group were lower than those of irbesartan group and benidipine group,Ccr of combined treatment group was higher than that of irbesar-tan group and benidipine group（P ﹤ 0. 05）;incidence of adverse reactions showed no significant differences in the three groups （P ﹥ 0. 05）. Conclusion Irbesartan and benidipine hydrochloride has notable curative effect in the treatment of hypertensive nephropathy,can improve the clinical symptoms and has less adverse reactions.