来曲唑与米非司酮治疗子宫肌瘤的临床疗效对比

Comparison of effect between letrozole and mifepristone in treating hysteromyoma

目的比较来曲唑与米非司酮治疗子宫肌瘤的临床疗效。方法选取2009—2013年曲阳仁济医院收治的子宫肌瘤患者135例,随机分为米非司酮组(62例)与来曲唑组(73例)。米非司酮组患者予以米非司酮治疗,来曲唑组患者予以来曲唑治疗。观察两组患者临床症状改善情况、子宫肌瘤体积、临床疗效、激素水平及不良反应发生情况。结果治疗前两组患者月经量增多、痛经、贫血、尿频尿急发生率比较,差异无统计学意义(P>0.05);治疗后两组患者痛经、尿频尿急发生率比较,差异无统计学意义(P>0.05),米非司酮组患者月经量增多、贫血发生率低于来曲唑组,差异有统计学意义(P<0.05);米非司酮组患者子宫肌瘤体积小于来曲唑组(P<0.05);米非司酮组患者临床疗效优于来曲唑组(P<0.05);治疗前两组患者血清黄体生成素(LH)、促卵泡激素(FSH)、雌激素(E2)及孕酮(P)水平比较,差异无统计学意义(P>0.05),治疗后米非司酮组患者血清LH、E2、P水平低于来曲唑组(P<0.05),治疗后两组患者FSH水平比较,差异无统计学意义(P>0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论米非司酮治疗子宫肌瘤的临床疗效显著,可改善患者临床症状,缩小子宫肌瘤体积,且不良反应小,安全性高。

Objective To compare the effect between letrozole and mifepristone in treating hysteromyoma. Methods A total of 135 patients with hysteromyoma were selected in Quyang Renji Hospital from January 2009 to December 2013,they were randomly divided into mifepristone group（62 cases）and letrozole group（73 cases）. Mifepristone group were given mife-pristone treatment,letrozole group were given letrozole treatment. Improvement of clinical symptoms,hysteromyoma volume, clinical effect,hormone level and incidence of adverse reactions between the two groups were compared. Results Before treat-ment,incidence of menstrual dosage increased,dysmenorrhea,anemia,frequent micturition and precipitant urine showed no significant differences between the two groups（P ﹥ 0. 05）,after treatment,incidence of dysmenorrhea,frequent micturition and precipitant urine showed no significant differences between the two groups（P ﹥ 0. 05）,incidence of menstrual dosage in-creased,anemia of mifepristone group was lower than that of letrozole group（P ﹤ 0. 05）;hysteromyoma volume of mifepristone group was less than that of letrozole group（P ﹤ 0. 05）;clinical effect of mifepristone group was better than that of letrozole group（P ﹤ 0. 05）;before treatment,luteinizing hormone（ LH）,follicle - stimulating hormone（ FSH）,estrogen（ E2 ）, progesterone（P）level showed no significant differences between the two groups（P ﹥ 0. 05）,after treatment,LH,E2 ,P lev-el of mifepristone group were lower than those of letrozole group（P ﹤ 0. 05）,FSH level showed no significant differences be-tween the two groups（P ﹥ 0. 05）;incidence of adverse reactions showed no significant differences between the two groups（P﹥ 0. 05）. Conclusion Mifepristone has notable curative effect in the treatment of hysteromyoma,can improve the clinical symptoms and reduce the hysteromyoma volume,has less adverse reactions and high safety.