ICU滞留慢性重症患者PCT和Cys-C的变化特点

The PCT and Cys-C variation of patients with severe retention in ICU residence

目的探讨ICU滞留的慢性重症患者血清降钙素原(PCT)和胱抑素C(Cys-C)的变化特点。方法回顾分析2006年1月-2014年6月医院ICU收治并长期滞留>60d患者的临床资料,统计比较患者入ICU第1、10、20、30、40、50、60天的PCT、Cys C的变化情况。结果年龄(76.32±13.74)岁,滞留ICU时间61d^3.48年,第60天的PCT、Cys C水平低于第1天(P<0.05),但Cys C却持续高于正常水平(>1.09mg/L)。经ICU治疗PCT可完全恢复至正常,但Cys-C经初期下降后,始终保持在偏高于正常值状态,随着ICU治疗时间的延长,有缓慢升高现象。结论慢性重症患者长期滞留ICU,依赖医疗设备和药物维持,能有效控制感染,但是肾脏功能慢性受损,不能完全恢复。

Objective To analysis the variation of PCT and Cys-C of patients with severe retention in ICU residence . Methods Retrospective analysis the clinical date of ICU residence 〉60d from January 2006 to June 2014.Compared the lev-el of PCT and Cys C in 1th,10th,20th,30th,40th,50th,60th.Results Age （76.32 ±13.74） years,ICU retention time （61-1271） d,the 60th days PCT,Cys-C levels were less than the 1th day （P〈0.05）,but Cys-C always above normal levels （〉1.09mg/L）.Conclusion Slow patients with severe long-term stay ICU,dependent on the maintenance of medical equip-ment and drugs ,can effectively control the infection ,but chronic impaired renal function can not be fully restored .