331株肠球菌的分布特征及耐药性探讨

331 Strains of Enterococcus Distribution and Drug Resistance

目的了解临床分离的肠球菌在医院感染中的分布及对抗菌药物的耐药性。为临床预防医院感染及抗感染治疗提供依据。方法回顾性分析2010年1月至2014年12月临床分离的331株肠球菌的分布及对抗菌药物的耐药性,并采用VITEK2 compact全自动细菌分析仪对331株肠球菌进行检测分析。结果 2010年1月至2014年12月共分离出331株肠球菌,其中分离出粪肠球菌220株(66.7%),屎肠球菌99株(30%),鸟肠球菌12株(3.3%),以粪肠球菌为主。在各种临床标本分布中,以阴道分泌物为最高,其次为尿液。粪肠球菌对红霉素、青霉素、环丙沙星、四环素的耐药率较高,对氨苄西林、喹喏酮类、氨基糖苷类药物耐药率比屎肠球菌低,除红霉素和四环素外,屎肠球菌对其他抗菌药物的耐药率均高于粪肠球菌。均未发现耐万古霉素的菌株。结论肠球菌感染以粪肠球菌、屎肠球菌为主。临床治疗应根据微生物实验室提供的药敏试验结果,合理选用抗菌药物。并根据其分离株的耐药特点,选择相应的治疗方案,从而提高治疗效果。

Objective To understand clinical isolated enterococcus in distribution and the antimicrobial resistance of nosocomial infection. To provide basis for clinical prevention of hospital infection and anti-infection treatment. Methods A retrospective analysis from January 2010 to December 2014, 331 strains of clinical isolated enterococcus distribution and the antimicrobial resistance, and adopts V1TEK2 compact automatic analyzer of 331 strains enterococcus bacteria detection analysis. Results From January 2010 to December 2014, a total of 331 strains isolated enterococcus, which isolated 220 strains （66.7%）, in enterococcus excrement enterococcus strains （30%）, 99 birds enterococcus strains （3.3%）, 12 is given priority to with dung enterococcus. Among various kinds of distribution of clinical specimens, is the highest with vaginal discharge, followed by urine. Dung enterococcus to erythromycin, penicillin, and ciprofloxacin, higher prevalence of tetracycline resistance, to ampicillin, quetiapine well ketone, aminoglycoside drug resistant rate is lower than excrement enterococcus, in addition to erythromycin and tetracycline, excrement enterococcus to other antimicrobial resistance were higher than dung enterococcus. Have found no vancomycin resistant strains. Conclusions Enterococcus infection is given priority to with dung enterococcus, excrement enterococcus. Clinical treatment should be according to the results of the microbiology laboratory provides the drug sensitive test of reasonable choice of antimicrobial agents. And according to the resistance characteristics of isolates, choose corresponding treatment, so as to improve treatment effect.