丁丙诺菲透皮贴联合普瑞巴林治疗老年带状疱疹后神经痛的临床观察

Clinical Effects of Combined Buprenorphine Transdermal Patch and Pregabalin on Gerontic Postherpetic Neuralgia

目的观察丁丙诺菲透皮贴联合普瑞巴林治疗老年带状疱疹后神经痛的临床效果。方法 60例老年带状疱疹后神经痛患者随机分为试验组和对照组。试验组:丁丙诺菲透皮贴联合普瑞巴林;对照组:单独应用口服普瑞巴林。治疗8周后记录两组患者用药前、用药后2周、4周、8周的疼痛评分(visual analogue scale,VAS)、睡眠评分、普瑞巴林日剂量及不良反应发生率。结果两组患者治疗后VAS评分明显低于治疗前(P<0.01),治疗后4周及8周试验组VAS评分明显低于对照组(P<0.05);用药治疗后两组患者睡眠质量明显改善(P<0.05);联合应用丁丙诺菲透皮贴后可明显减少试验组普瑞巴林的用量(P<0.05);联合应用丁丙诺菲透皮贴可以显著减少普瑞巴林相关不良反应头晕、嗜睡的发生率(P<0.05)。结论丁丙诺菲透皮贴联合普瑞巴林对老年带状疱疹后神经痛患者的临床效果优于单独应用普瑞巴林,不良反应较小。

Objective To observed the effect of buprenorphine transdermal patches combined with pregabalin in gerontic patients with PHN. Methods 60 patients were divided into experimental group and control group randomly. Patients of experimental group were treated with buprenorphine transdermal patches combined with pregabalin. The control group were orally administered pregabalin simply. The pain scores （VAS scores）, sleep scores, doses of pregabalin and adverse reactions at each time point were recorded. Results There were a significant decline in VAS scores and sleep scores after treatment in 2 groups（P〈0.01）. Compared with the control group, the VAS scores and the dose of pregabalin were significantly lower at 4, 8 weeks after treatment（P〈0.05）. The incidence of dizzy and drowsiness were higher in control group（P〈0.05）, but there were no significant difference in the incidence of other side effects. Conclusion The combination of buprenorphine transdermal patches and pregabalin is effective and safe for the gerontic patients with PHN.