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健康志愿者静脉滴注奥美拉唑药代动力学和临床药效学分析

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摘要 目的研究分析10名健康志愿者静脉滴注奥美拉哇的药代动力学和临床药效学情况。方法药动学参数测定采用HPLC方法,并对胃内酸抑制情况进行计算以确定奥美拉唑药效。结果奥美拉唑药时曲线符合二室开放模型,10名受试者基础胃酸都能在一定程度上受到抑制。结论结果表明静脉滴注80mg奥美拉唑可显著抑制胃酸分泌,缓解胃酸过多。
作者 国宏伟
出处 《海峡药学》 2015年第6期265-266,共2页 Strait Pharmaceutical Journal
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