离子液体中ATRP法合成MCC-g-PGMA分子及其组装研究

Synthesis of MCC-g-PGMA by ATRP in ionic liquids and its self-assemble

在氯化1-烯丙基-3-甲基咪唑([AMIM]Cl)离子液体中溶解天然纤维素,采用ATRP技术合成了微晶纤维素接枝聚甲基丙烯酸缩水甘油酯(MCC-g-PGMA)分子。研究表明:[AMIM]Cl对微晶纤维素有较好的溶解性。最佳ATRP接枝聚合反应条件如下:n(GMA)∶n(乙二胺)∶n(CuBr)为100∶4∶1,反应温度为25℃,反应时间为4.0h,接枝率可达50%以上,分子质量分布较窄。FT-IR和SEM测试表明:在微晶纤维素上接枝了PGMA,共聚物分子PGMA接枝到MCC后,改变了其表面形态。TEM观察发现MCC-g-PGMA在不同溶剂中可组装成不同形态,在药物载体方面具有明显的应用前景。

The microcrystalline cellulose（MCC）is dissolved in ionic liquids 1-allyl-3-methyl imidazolium chloride.Then MCCg-PGMA is synthesized by ATRP in ionic liquid[AMIM]Cl to graft GMA onto MCC.The experiment proves that microcrystalline cellulose can well dissolve in[AMIM]Cl.Optimum mole ratio of GMA/ethanediamine/CuBr is attained at 100∶4∶1.The temperature and reaction time are 25 ℃ and 4.0hrespectively.The grafting efficiency can reach more than 50% and the distribution of molecular weight of MCC-g-PGMA is narrow.FT-IR and SEM tests show that the synthesis of MCC-g-PGMA graft copolymer is successful and PGMA grafted to the MCC changes its surface morphology.TEM indicates that MCC-gPGMA could be assembled into different forms in different solvents.It has a perfect application prospect in the field of drug carrier.