重症急性胰腺炎的持续肾脏替代治疗

Application of continuous renal replacement therapy on severe acute pancreatitis

重症急性胰腺炎发病急骤,机体可产生大量炎症介质,进而导致多脏器功能障碍综合征,病情变化快,病死率极高。持续肾脏替代治疗(CRRT)应用于重症急性胰腺炎患者,可以有效清除炎症介质,维持机体内环境,有利于胰腺、肺、肾等重要脏器功能的改善以及恢复,避免病情进一步恶化。CRRT是辅助治疗重症急性胰腺炎患者的有效方法之一,可能对重症急性胰腺炎患者的预后有改善作用。

Excessive activation of inflammatory mediators cascade during severe acute pancreatitis （SAP） is a major cause of multiple organ dysfunction and is associated with a high mortality of SAP. Continuous renal replacement therapy （CRRT） can effectively reduce the level of inflammatory mediators and restore immune homeostasis, improve pancreatic, respiratory and renal function, decrease the mortality rate of SAP. CRRT is one of effective approach treatment in SAP patients. It may improve the prognosis of SAP.