摘要
目的 研究红花Carthamus tinctorius的化学成分。方法 采用硅胶、Sephadex LH-20和pre-HPLC等多种色谱技术进行分离纯化,运用MS、NMR等波谱学方法以及结合文献数据鉴定化合物结构。结果 从红花乙醇提取物中分离得到20个化合物,分别鉴定为山柰酚-3-O-β-D-葡萄糖基-(1→2)-β-D-葡萄糖苷(1)、野黄芩素(2)、正二十六烷酸(3)、(2S)-1-Oheptatriacontanoyl glycerol(4)、4,4-二甲基庚二酸(5)、5,7,4′-三羟基-6-甲氧基黄酮-3-O-β-D-芸香糖苷(6)、n-tetratriacont-20,23-dienoic acid(7)、香草酸(8)、没食子酸(9)、tetrephthalic acid mono-[2-(4-carboxy-phenoxycarbonyl)-vinyl]ester(10)、七叶亭(11)、6-羟基芹菜素-6-O-β-D-葡萄糖苷-7-O-β-D-葡萄糖醛酸苷(12)、槲皮素-3,7-二-O-β-D-葡萄糖苷(13)、6-甲氧基山柰酚(14)、紫丁香苷(15)、反式-1-(4′-羟基苯基)-丁-1-烯-3-酮(16)、熊果酸(17)、1-hexadecanoyl propan-2,3-diol(18)、柠黄醇(19)、东莨菪内酯(20)。结论 化合物1、5、7、10、18、19为首次从红花属植物中分离得到,化合物2-4、6、8、9、11、17、20为首次从红花中分离得到。
Objective To investigate the chemical constituents of Carthamus tinctorius. Methods Compounds were isolated by a combination of various column chromatography over silica gel, Sephadex LH-20, and pre-HPLC and their structures were identified by spectral analytical methods of MS and NMR and/or comparison with literature data. Results Twenty compounds were isolated from the ethanol extract of C. tinctorius. Their structures were identified as kaempferol-3-O-β-D-glucosyl-(1→2)-β-D-glucoside (1), scutellarein (2), hexacosanoic acid (3), (2S)-1-O-heptatriacontanoyl glycerol (4), 4,4-dimethyl heptanedioie (5), 5,7,4'-trihydroxy-6- methoxyflavone-3-O-β-D-rutinoside (6), n-tetratriacont-20,23-dienoic acid (7), vanillic acid (8), gallic acid (9), tetrephthalic acid mono-[2-(4-earboxy-phenoxycarbonyl)-vinyl] ester (10), esculetin (11), 6-hydroxyapigenin-6-O-β-D-glucoside-7-O-β-D-glucuronide (12), quercetin-3,7-di-O-β-D-gtucoside (13), 6-methoxykaempferol (14), syringing (15), E-1-(4'-hydroxypheny)-but-l-en-3-one (16), ursolic acid (17), 1-hexadecanoyl propan-2,3-diol (18), citrostadienol (19), and seopoletin (20). Conclusion Compounds 1, 5, 7, 10, 18, and 19 are isolated from the plants of Carthamus L. for the first time, and compounds 2-4, 6, 8, 9, 11, 17, and 20 are obtained from C. tinctorius for the first time.
出处
《中草药》
CAS
CSCD
北大核心
2015年第13期1872-1877,共6页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81274058)
国家科技支撑计划项目(2008BAI51B01)