牛蒡根水提物对高血压大鼠血管重塑的影响

Effect of aqueous extract from roots of Arctium lappa on vascular remolding in hypertensive rats

目的观察牛蒡根水提物对高血压大鼠血管重塑的影响及其机制。方法 50只雌性Wistar大鼠用N-硝基-L-精氨酸(L-NNA)建立高血压大鼠模型,随机分为模型组,阳性对照组(卡托普利15 mg/kg),牛蒡根水提物低、中、高剂量(0.5、1.0、2.0 g/kg)组,连续ig给药6周,检测大鼠收缩压(SBP),血清血管紧张素II(Ang-II)、内皮素-1(ET-1)、肿瘤坏死因子-α(TNF-α)水平,左心室质量指数(LVWI)及胸主动脉中膜厚度。结果与对照组比较,模型组大鼠SBP,血清Ang-II、ET-1、TNF-α水平,LVWI及胸主动脉中膜厚度显著升高(P<0.05);与模型组比较,各给药组大鼠SBP、血清Ang-II、ET-1、TNF-α水平,LVWI及胸主动脉中膜厚度均显著降低(P<0.05)。结论牛蒡根水提物可改善高血压大鼠血管重塑。

Objective To observe the effect of aqueous extract from roots of Arctium lappa （AERAL） on vascular remolding in hypertensive rats. Methods The hypertensive rat model was induced by N-nitro-L-arginine from 50 female Wistar rats, and randomly divided into model control group, positive control group （15 mg/kg）, low-, mid-, and high-dose AERAL （0.5, 1.0, and 2.0 g/kg）, groups. After six weeks of continuous gavage administration, rat tail artery systolic pressure, angiotensin II （Ang-II）, endothelin-1 （ET-1）, tumor necrosis factor-α （TNF-α）, left ventricular mass index （LVWI）, and thickness of thoracic aortic tunica media （TTATM） were detected. Results Compared with the normal control group, Ang-II, ET-1, TNF-α, LVWI, and TTATM were increased and rat tail artery systolic pressure was elevated in the model control group, with significant differences between the two groups （P 〈 0.05）; Compared with the model＇control group, rat tail artery systolic pressure in each treatment groups declined, serum Ang-II, ET-1, TNF-α, LVWI, and TTATM were all lowered, showing significant differences among them （P 〈 0.05）. Conclusion AERAL can significantly improve vascular remolding in rats with hypertension.